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Published on: November 10, 2017

[Dyslipidemia]

Yamato Mashimo1, Tomomi Maeda, Tamio Teramoto

  • 1Department of Internal Medicine, Teikyo University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|May 25, 2012
PubMed

Insights

Controlling low-density lipoprotein (LDL) cholesterol and secondary risk factors like high-density lipoprotein (HDL) cholesterol is crucial for preventing atherosclerotic diseases. Integrated management of these lipid parameters is key for effective dyslipidemia treatment.

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Atherosclerosis Research

Context:

  • Low-density lipoprotein (LDL) cholesterol is a primary risk factor for atherosclerotic diseases, including coronary artery and cerebrovascular diseases.
  • Secondary risk factors such as high-density lipoprotein (HDL) cholesterol, non-HDL-C, small dense LDL, remnant-like particle cholesterol (RLP-C), and oxidized LDL also contribute to atherosclerosis.
  • Dyslipidemia management requires a comprehensive approach beyond just LDL-C.

Purpose:

  • To emphasize the established role of LDL cholesterol in atherosclerosis.
  • To highlight the significance of secondary lipid risk factors in disease development.
  • To underscore the necessity of integrating multiple lipid parameters for effective prevention and treatment strategies.

Summary:

  • LDL cholesterol is the principal established risk factor for atherosclerotic conditions like coronary artery disease and cerebrovascular disease.
  • Additional risk factors include HDL cholesterol, nonHDL-C, small dense LDL, RLP-C, and oxidized LDL, all contributing to atherosclerosis.
  • Effective prevention and treatment of dyslipidemia necessitate the integrated control of these diverse lipid risk factors.

Impact:

  • Provides a foundational understanding of lipid-based atherosclerosis risk.
  • Informs clinical practice regarding comprehensive dyslipidemia assessment.
  • Guides the development of targeted therapeutic strategies for cardiovascular disease prevention.

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