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Published on: August 16, 2018
Sesquiterpenoids from Incarvillea arguta: absolute configuration and biological evaluation
Yong-Ming Yan1, Gui-Sheng Wu, Xiao-Ping Dong
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Abstract:
Diincarvilones A-D (1-4), incarvilone A (5), and a known compound, argutosine B (6), were isolated from Incarvillea arguta. The structures, including the absolute configurations of the new compounds, were determined by NMR spectroscopy, X-ray diffraction analysis, CD spectroscopy, and a variety of computational methods. The biological properties of these substances, including effects on intracellular Ca(2+) influx, nitric oxide (NO) production, and human cancer cells, were evaluated. The results showed that at the concentration of 10 μM (in HBSS buffer) diincarvilones A and B cause a persistent increase in cytoplasmic calcium levels in A549 cells.
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