Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Drug Biotransformation: Biological01:19

Factors Affecting Drug Biotransformation: Biological

Biological factors significantly impact drug metabolism, influencing drug clearance, efficacy, and potential toxicity.
Species differences: Variations in enzyme systems across species can cause disparities in drug metabolism. For instance, humans may metabolize certain drugs faster than rodents, altering therapeutic effects.
Strain differences: Genetic variations within a species can result in differing enzyme activity, impacting drug response and toxicity. For example, some mouse strains may...
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The importance of self-care and contextual factors: A process evaluation of a recovery intervention for new nurses.

International journal of nursing studies advances·2026
Same author

Candidate prognostic factors of presenteeism among French workers: an exploratory longitudinal study.

BMC public health·2026
Same author

PREVENIR-IVF: study protocol for a prospective multicentre randomized open comparative trial, which explores the efficacy of a multidisciplinary platform reducing and preventing reprotoxic environmental exposures in subfertile couples on live birth rate after assisted reproduction treatment.

Trials·2025
Same author

Quick Returns: A Quasi-Experimental Field Study on the Effects on Sleep, Fatigue and Cognitive Performance.

Journal of sleep research·2025
Same author

High occupational physical activity and its combined effect with leisure-time physical activity on cardiovascular disease and mortality: systematic reviews and meta-analyses.

Occupational and environmental medicine·2025
Same author

The impact of breaking up prolonged sitting with physical activity during simulated dayshifts and nightshifts on sleep architecture: a randomised controlled trial.

Scientific reports·2025

Related Experiment Video

Updated: May 22, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Shiftwork and metabolic dysfunction.

Philip Tucker1, Jean-Claude Marquié, Simon Folkard

  • 1Department of Psychology, Swansea University, Swansea, UK. p.t.tucker@swansea.ac.uk

Chronobiology International
|May 25, 2012
PubMed
Summary
This summary is machine-generated.

Shiftwork increases the risk of developing metabolic syndrome, characterized by obesity, high blood pressure, and abnormal glucose levels. Prolonged exposure, over 10 years, further elevates this risk, highlighting the need for health monitoring in shift workers.

Related Experiment Videos

Last Updated: May 22, 2026

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

Area of Science:

  • Occupational Health
  • Metabolic Health
  • Epidemiology

Background:

  • Shiftwork is associated with increased prevalence of health issues, potentially linked to metabolic syndrome.
  • Previous research indicates a link between shiftwork and metabolic syndrome, but the impact of exposure duration is less understood.

Purpose of the Study:

  • To confirm the association between shiftwork and metabolic syndrome.
  • To investigate how the duration of shiftwork exposure influences the risk of developing metabolic syndrome.

Main Methods:

  • Analysis of data from the VISAT study (1757 participants, 989 shiftworkers).
  • Statistical adjustment for covariates including age, sex, socioeconomic status, smoking, alcohol intake, perceived stress, and sleep difficulty.
  • Examination of metabolic syndrome symptoms in relation to shiftwork status and duration of rotating shiftwork exposure.

Main Results:

  • Shiftworkers were more likely to exhibit metabolic syndrome symptoms (OR 1.78, 95% CI 1.03-3.08), independent of strain or sleep difficulty.
  • Participants with over 10 years of rotating shiftwork experience showed a higher likelihood of metabolic syndrome (OR 1.96, 95% CI 1.03-3.75) compared to dayworkers.

Conclusions:

  • Shiftwork is confirmed as a risk factor for metabolic syndrome.
  • Exposure duration, particularly over 10 years of rotating shiftwork, significantly increases metabolic syndrome risk.
  • Occupational health monitoring should focus on metabolic dysfunction in long-term shift workers.