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Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Determination

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Related Experiment Video

Updated: May 22, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

Published on: February 16, 2017

Wnt signaling and forebrain development.

Susan J Harrison-Uy¹, Samuel J Pleasure

¹Department of Neurology, University of California, San Francisco, California 94143, USA.

Cold Spring Harbor Perspectives in Biology

|May 25, 2012

Summary

This summary is machine-generated.

Wnt signaling is crucial for forebrain development, regulating regional identity and progenitor cell behavior. It controls cell expansion and differentiation, ultimately influencing neurogenesis and cell-type specification.

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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

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Last Updated: May 22, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions

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Published on: February 16, 2017

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Area of Science:

Neuroscience
Developmental Biology
Molecular Biology

Background:

Wnt signaling pathway components are precisely regulated during forebrain development.
Wnts are critical for establishing regional identity in the developing forebrain.
Wnt signaling interacts with BMP, FGF, and Shh pathways for forebrain patterning.

Purpose of the Study:

To elucidate the role of Wnt signaling in forebrain development.
To understand how Wnt signaling regulates progenitor cell behavior and neurogenesis.
To investigate Wnt signaling's contribution to cell-type specification.

Main Methods:

Analysis of Wnt pathway component expression during forebrain development.
Investigating the effects of Wnt signaling on cortical hem and adjacent neuroepithelium.
Studying the dynamic regulation of cortical progenitor cells by Wnt signaling.

Main Results:

Wnt signaling from the cortical hem directs neuroepithelium expansion and cell-type specification.
Wnt signaling, alongside other pathways, governs dorsal-ventral forebrain patterning.
Wnt signaling dynamically controls cortical progenitor cells, promoting radial glia expansion and intermediate progenitor differentiation.

Conclusions:

Wnt signaling is a key regulator of forebrain regional identity and patterning.
Wnt signaling plays a dynamic role in cortical progenitor cell proliferation and differentiation.
Wnt signaling is implicated in the cell-type specification during forebrain development.