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Bode Plots Construction01:24

Bode Plots Construction

The Bode plot is an essential tool in control system analysis, mapping the frequency response of a system through a magnitude plot and a phase plot, both against a logarithmic frequency axis. To construct a Bode plot, consider the transfer function H(ω):

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Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing
07:07

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing

Published on: December 13, 2016

Bioimpedance of soft tissue under compression.

R E Dodde1, J L Bull, A J Shih

  • 1Biomedical Engineering Department, University of Michigan, Ann Arbor, MI, USA. dodderob@umich.edu

Physiological Measurement
|May 25, 2012
PubMed
Summary

Compression affects porcine spleen tissue bioimpedance. Increased compression alters intracellular and extracellular resistance and membrane capacitance, suggesting fluid loss and potential cell rupture during mechanical changes.

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Last Updated: May 22, 2026

Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing
07:07

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Published on: December 13, 2016

Evaluation of Fluid Overload by Bioelectrical Impedance Vectorial Analysis
07:17

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Published on: August 17, 2022

Area of Science:

  • Biophysics
  • Tissue Mechanics
  • Biomaterials

Background:

  • Bioimpedance analysis is a non-invasive technique to assess tissue composition.
  • Understanding tissue mechanical properties is crucial for various applications, including medical device design and surgical procedures.
  • Porcine spleen tissue serves as a relevant model for studying soft tissue behavior under mechanical stress.

Purpose of the Study:

  • To investigate the compression-dependent bioimpedance characteristics of porcine spleen tissue.
  • To analyze the changes in extracellular and intracellular makeup during tissue compression using a Cole-Cole model.
  • To correlate mechanical compression with alterations in tissue electrical properties.

Main Methods:

  • Compression-dependent bioimpedance measurements were performed on porcine spleen tissue.
  • A custom tetrapolar probe and bioimpedance circuitry were utilized for data acquisition.
  • A Cole-Cole model was employed to analyze the nonlinear compositional changes.
  • Tissue compression was incrementally increased up to 80%.

Main Results:

  • Up to 50% compression, both intracellular and extracellular resistances increased, while bulk membrane capacitance decreased.
  • At 80% compression, intracellular resistance (107% increase) and bulk membrane capacitance (64% increase) rose, while extracellular resistance decreased (32% decrease).
  • Intracellular resistance showed double asymptotic curves against peak tissue pressure, indicating distinct mechanical change phases.

Conclusions:

  • Compression significantly alters the bioimpedance parameters of porcine spleen tissue.
  • Observed changes suggest fluid loss and potential cellular alterations, including cell rupture and material exudation, under high compression.
  • The findings provide insights into the mechanical-electrical coupling within soft tissues.