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Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
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Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...

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Stability and Structure of Bat Major Histocompatibility Complex Class I with Heterologous β2-Microglobulin
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Hantavirus structure--molecular interactions behind the scene.

Jussi Hepojoki1, Tomas Strandin1, Hilkka Lankinen1

  • 1Department of Virology, Peptide and Protein Laboratory, Infection Biology Research Program, Haartman Institute, University of Helsinki, Finland.

The Journal of General Virology
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Hantaviruses, rodent-borne viruses, possess unique structural proteins and assembly mechanisms within the Bunyaviridae family. This review details their structure, interactions, and assembly, comparing them to other bunyaviruses.

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Area of Science:

  • Virology
  • Structural Biology
  • Molecular Biology

Background:

  • Hantaviruses are unique among Bunyaviridae for rodent transmission, unlike arthropod-borne relatives.
  • Their genome comprises three RNA segments encoding key structural proteins: nucleocapsid (N), glycoproteins (Gn, Gc), and RNA-dependent RNA-polymerase.
  • Virions are enveloped, spherical, 120-160 nm in diameter, with surface glycoprotein spikes.

Purpose of the Study:

  • To review the structural components of hantaviruses.
  • To elucidate the mechanisms of virion assembly and integrity.
  • To compare hantavirus structure with other bunyaviruses.

Main Methods:

  • Literature review focusing on structural virology and molecular biology of hantaviruses.
  • Analysis of existing data on hantavirus protein composition and organization.
  • Comparative analysis with structurally characterized bunyaviruses.

Main Results:

  • Detailed description of hantavirus structural proteins (N, Gn, Gc, polymerase) and their roles.
  • Exploration of ribonucleoprotein formation and lipid envelope incorporation.
  • Discussion of glycoprotein spike formation and virion morphology.

Conclusions:

  • Hantavirus virion structure is critical for its lifecycle and infectivity.
  • Understanding assembly mechanisms provides insights into viral pathogenesis.
  • Comparative structural analysis highlights evolutionary relationships within Bunyaviridae.