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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

Updated: May 22, 2026

High efficiency, Site-specific Transfection of Adherent Cells with siRNA Using Microelectrode Arrays (MEA)
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High efficiency, Site-specific Transfection of Adherent Cells with siRNA Using Microelectrode Arrays (MEA)

Published on: September 13, 2012

Targeted delivery to single cells in precisely controlled microenvironments.

John M Collins1, Ruby T S Lam, Ziping Yang

  • 1NanoInk, Inc. 8025 Lamon Ave, Skokie, IL, USA. jcollins@nanoink.net

Lab on a Chip
|May 25, 2012
PubMed
Summary
This summary is machine-generated.

Researchers developed a method to precisely deliver different materials to individual cells. This technique enables single-cell analysis by controlling cellular microenvironments, overcoming issues with cell heterogeneity in vitro.

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Related Experiment Videos

Last Updated: May 22, 2026

High efficiency, Site-specific Transfection of Adherent Cells with siRNA Using Microelectrode Arrays (MEA)
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07:05

Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip

Published on: September 27, 2019

Area of Science:

  • Cell Biology
  • Biotechnology
  • Materials Science

Background:

  • Cellular heterogeneity complicates in vitro cell function analysis, leading to averaged observations.
  • Existing methods often struggle to address variations within cell populations.
  • Sub-cellular scale patterning (< 10 μm) is crucial for precise single-cell manipulation.

Purpose of the Study:

  • To develop a method for simultaneous, nanoscale patterning of multiple materials.
  • To enable the fabrication of multiplexed cellular microenvironment arrays.
  • To facilitate the delivery of diverse materials to single or few cells for advanced assays.

Main Methods:

  • Utilized nanoscale precision patterning to create multiplexed microenvironment arrays.
  • Developed a technique for simultaneous delivery of multiple materials to the same substrate.
  • Applied the method to deliver Calcein AM, Calcein Red AM, and quantum dots to live single or few cells.

Main Results:

  • Successfully delivered distinct materials (dyes and quantum dots) to spatially defined single or few cells.
  • Demonstrated the ability to create cellular microenvironments with nanoscale precision.
  • Achieved delivery of materials to cells located hundreds of microns apart on the same substrate.

Conclusions:

  • The developed patterning and delivery technique overcomes limitations of cellular heterogeneity in vitro.
  • Enables precise control over the microenvironment for individual cells.
  • Opens new possibilities for high-throughput, single-cell-based assays and analyses.