Related Experiment Video
Updated: May 22, 2026

Transmesenteric Laparoscopic Pyeloplasty in Trendelenburg Position for Horseshoe Kidney with Hydronephrosis
Published on: July 8, 2025
Missed opportunities in the treatment of pediatric appendicitis
Justin Lee1, David B Tashjian, Kevin P Moriarty
1Baystate Children's Hospital, Tufts University School of Medicine, Springfield, MA 01199, USA. Justin.Lee@tufts.edu
Insights
Delaying pediatric appendicitis treatment beyond two days increases complications and necessitates more complex surgeries. Certain comorbidities significantly elevate the risk of treatment delay in children.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Healthcare Management
Background:
- Pediatric acute appendicitis is a common surgical emergency.
- In-hospital delays in treatment can lead to adverse outcomes.
- Identifying factors associated with delay is crucial for improving patient care.
Purpose of the Study:
- To evaluate the outcomes of in-hospital delay in treating pediatric acute appendicitis.
- To identify co-morbidities associated with delayed treatment.
Main Methods:
- Retrospective analysis of the National Inpatient Sample (NIS) database from 2000 to 2008.
- Defined immediate treatment as occurring on hospital day 0 or 1.
- Defined delayed treatment as occurring on hospital day 2 or later.
Main Results:
- Out of 683,016 pediatric appendicitis cases, 2.6% experienced treatment delay.
- Co-morbidities associated with delay included ALL, AML, neutropenia, and ovarian cysts.
- Delayed treatment correlated with increased rates of drainage procedures, cecectomy, hemicolectomy, small bowel repair, and resection.
Conclusions:
- In-hospital delay in treating pediatric appendicitis beyond two days is linked to significant negative outcomes.
- Complications, economic burden, and complex surgical management increase with delayed treatment.
- A co-morbidity index can identify high-risk patients prone to treatment delay.
Introduction:
This study sought to evaluate the outcomes of in-hospital delay and determine associated co-morbidities in the treatment of pediatric acute appendicitis.
Methods:
This was a retrospective analysis of the national inpatient sample from 2000 to 2008. Immediate treatment was defined as treatment in hospital day 0 or 1. Delay in treatment was defined as treatment in hospital day 2 and beyond.
Results:
During the study period, 683,016 pediatric appendicitis were identified. 17,737 (2.6%) experienced a delay in treatment. Multivariate analysis identified associated co-morbidities for delay in treatment: ALL (OR 12.84, CI 11.04-14.94), AML (OR 9.41, CI 7.58-11.68), neutropenia (OR 5.53, CI 4.60-6.65), and ovarian cyst without torsion (OR 3.17, CI 2.94-3.42). Surgical management included more than 13-fold increase in drainage procedures (5.5 vs. 0.4%), sixfold increase in cecectomy (1.2 vs. 0.2%), 14-fold increase in hemicolectomy (1.4 vs. 0.1%), 11-fold increase in small bowel laceration suture repair (1.1 vs. 0.1%), and 15-fold increase in small bowel resection (1.5 vs. 0.1%).
Conclusions:
In-hospital delay beyond 2 days is associated with significant negative outcomes with regard to complications, economic burden, and subsequent surgical management. Using the co-morbidity index, high-risk co-morbidities with associated delay in treatment were identified.
Related Concept Videos
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Pharmacokinetics in Pediatric Patients: Drug Excretion
Acute Pyelonephritis II: Diagnostic Studies and Management