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Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Sex Linked Disorders01:43

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Related Experiment Video

Updated: May 22, 2026

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
08:42

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research

Published on: July 31, 2017

Sharing heterogeneous data: the national database for autism research.

Dan Hall1, Michael F Huerta, Matthew J McAuliffe

  • 1OMNITEC Solutions, Inc., 6001 Executive Boulevard, Suite 7161, Rockville, MD 20892-9640, USA. halldan@mail.nih.gov

Neuroinformatics
|May 25, 2012
PubMed
Summary

The National Database for Autism Research (NDAR) provides a secure platform for sharing autism spectrum disorder data. It aims to accelerate scientific discovery by making data from over 25,000 participants accessible to researchers.

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Last Updated: May 22, 2026

A Familiarization Protocol Facilitates the Participation of Children with ASD in Electrophysiological Research
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Published on: July 31, 2017

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Published on: September 6, 2024

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Psychology

Background:

  • Autism spectrum disorder (ASD) research requires large, diverse datasets for robust analysis.
  • Data silos and lack of standardized sharing hinder scientific progress in understanding ASD.
  • The need for a centralized, secure repository for ASD research data is critical.

Purpose of the Study:

  • To establish and maintain a secure data repository for autism spectrum disorder research.
  • To facilitate data sharing and collaboration among ASD investigators.
  • To accelerate scientific discovery through harmonized data and accessible research results.

Main Methods:

  • Development of a secure online research data repository (NDAR).
  • Implementation of data harmonization protocols for diverse datasets.
  • Establishment of a portal for qualified investigators to access de-identified data.

Main Results:

  • NDAR hosts data from over 25,000 research participants.
  • A secure portal provides access to de-identified ASD research data for qualified investigators.
  • Summary information about available data is publicly accessible.

Conclusions:

  • The NDAR serves as a vital resource for the autism research community.
  • Facilitating data sharing through NDAR promotes collaborative and accelerated scientific discovery in ASD.
  • The repository supports the advancement of knowledge regarding autism spectrum disorder.