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Mechanical Testing of Mouse Carotid Arteries: from Newborn to Adult
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Published on: February 23, 2012

Progressive structural and biomechanical changes in elastin degraded aorta.

Ming-Jay Chow1, Jarred R Mondonedo, Victor M Johnson

  • 1Department of Mechanical Engineering, Boston University, 110 Cummington Street, Boston, MA 02215, USA.

Biomechanics and Modeling in Mechanobiology
|May 25, 2012
PubMed
Summary

This study modeled aortic aneurysm by degrading elastin in arteries. Elastin degradation alters mechanical properties through distinct stages, potentially explaining artery dilation during aneurysm development.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Materials Science

Background:

  • Aortic aneurysm involves structural changes like elastin degradation and collagen deposition.
  • Understanding the link between arterial composition and mechanical behavior is crucial for aneurysm research.

Purpose of the Study:

  • To investigate the relationship between mechanical properties and structural/biochemical changes in arteries.
  • To model aneurysm progression using chemical degradation of elastin.

Main Methods:

  • Porcine thoracic aortas were chemically digested using purified elastase.
  • Mechanical properties were assessed using a biaxial tensile testing device at various time points (6-96 hours).

Main Results:

  • Elastin disruption led to increased artery dilation without loading.
  • Digested arteries exhibited four mechanical property stages: initial-softening, elastomer-like, extensible-but-stiff, and collagen-scaffold-like.
  • An S-shaped stress-strain behavior, previously unreported, was observed during enzyme digestion.

Conclusions:

  • Gradual elastin structural changes drive distinct mechanical property transitions in arteries.
  • These transitions may represent a critical stage contributing to artery dilation in aneurysm formation.