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Related Experiment Video

Updated: May 22, 2026

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

Neuropathic pain: is quantitative sensory testing helpful?

Elena K Krumova1, Christian Geber, Andrea Westermann

  • 1Department of Pain Medicine, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr-University Bochum, Germany. Elena.Krumova@rub.de

Current Diabetes Reports
|May 25, 2012
PubMed
Summary

Quantitative sensory testing (QST) precisely measures sensory perception to diagnose neuropathic pain and small-fibre neuropathy. This method aids in early detection and personalized treatment strategies for various pain syndromes.

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Area of Science:

  • Neuroscience
  • Neurology
  • Pain Medicine

Background:

  • Neuropathic pain results from somatosensory system damage, presenting with positive and negative sensory symptoms.
  • Quantitative sensory testing (QST) evaluates sensory perception and nerve fiber function (large A-beta, small A-delta, C fibers).

Purpose of the Study:

  • To highlight QST's role in diagnosing neuropathic pain and small-fibre neuropathy.
  • To emphasize QST's ability to detect both positive and negative sensory signs, unlike other methods.
  • To showcase QST's utility in identifying early-stage subclinical neuropathy, particularly in diabetic patients.

Main Methods:

  • Standardized application of controlled mechanical and thermal stimuli.
  • Assessment of detection and pain thresholds, and stimulus-response curves.

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Last Updated: May 22, 2026

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing
09:16

Dynamic Quantitative Sensory Testing to Characterize Central Pain Processing

Published on: February 16, 2017

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery
07:14

A Quantitative Sensory Testing Paradigm to Obtain Measures of Pain Processing in Patients Undergoing Breast Cancer Surgery

Published on: January 18, 2018

  • Utilizing normative data for individual neuropathy diagnosis.

    • Main Results:

    • QST detects positive sensory signs missed by conventional electrophysiology.
    • QST aids in diagnosing isolated small-fibre neuropathy.
    • Early detection of subclinical diabetic neuropathy is possible, aiding in diabetic foot ulceration risk identification.

    Conclusions:

    • QST provides a detailed sensory profile valuable for understanding pain mechanisms in neuropathic pain syndromes.
    • Accurate sensory phenotyping via QST may guide future treatment selection based on underlying pain mechanisms.