Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

COP Coated Vesicles

COP Coated Vesicles

Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of different...

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Co-templating of polyoxoniobates and silicate/germanate trimer-rings in crystals and inorganic gels.

Chemical science·2026

Same author

Revisiting the Robin-Day Classification through Switchable Electronic States in Multimetallic Vanadium Oxides.

Journal of the American Chemical Society·2026

Same author

Building block approach to technetium-substituted polyoxotungstates.

Chemical communications (Cambridge, England)·2026

Same author

Back to Basics: Lanthanide and Heavy Actinide Chelation at High pH by Niobium Polyoxometalates.

Inorganic chemistry·2026

Same author

Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography.

Proceedings of the National Academy of Sciences of the United States of America·2025

Same author

Speciation-Dependent Solvent Extraction of Polyoxopalladates Toward Separation of Critical Materials.

Angewandte Chemie (International ed. in English)·2025

Search research articles

Related Experiment Video

Updated: May 22, 2026

Triplet Fusion Upconversion Nanocapsule Synthesis

Triplet Fusion Upconversion Nanocapsule Synthesis

Published on: September 7, 2022

A journey inside the U28 nanocapsule.

Adrià Gil¹, David Karhánek, Pere Miró

¹Institute of Chemical Research of Catalonia (ICIQ), Avda. Països Catalans, 17. 43007 Tarragona, Spain.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|May 25, 2012

Summary

Anionic uranyl-peroxide nanocapsules trap ions, but their structure is unclear. Density Functional Theory (DFT) calculations revealed the capsule geometry and disorder origin, showing cation influence on stability and properties.

More Related Videos

Utilization of Capsules for Negative Staining of Viral Samples within Biocontainment

Utilization of Capsules for Negative Staining of Viral Samples within Biocontainment

Published on: July 19, 2017

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Related Experiment Videos

Last Updated: May 22, 2026

Triplet Fusion Upconversion Nanocapsule Synthesis

Triplet Fusion Upconversion Nanocapsule Synthesis

Published on: September 7, 2022

Utilization of Capsules for Negative Staining of Viral Samples within Biocontainment

Utilization of Capsules for Negative Staining of Viral Samples within Biocontainment

Published on: July 19, 2017

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Area of Science:

Inorganic Chemistry
Materials Science
Computational Chemistry

Background:

Anionic uranyl-peroxide nanocapsules exhibit complex structures.
Crystallographic disorder hinders X-ray diffraction analysis of encapsulated species.
Understanding the factors influencing nanocapsule stability and properties is crucial.

Purpose of the Study:

To fully characterize the geometry of anionic uranyl-peroxide nanocapsules.
To elucidate the origin of crystallographic disorder within these systems.
To investigate the influence of entrapped cations on nanocapsule stability and electronic properties.

Main Methods:

Density Functional Theory (DFT) calculations were employed for complete geometric characterization.
Experimental data was used to validate theoretical findings.
Analysis of electronic character and redox properties was performed.

Main Results:

DFT calculations successfully characterized the complex nanocapsule geometry.
The origin of crystallographic disorder was explained through theoretical modeling.
Nanocapsule stability was found to be significantly influenced by the nature of the entrapped cations.
Excellent agreement was achieved between experimental and theoretical results for electronic and redox properties.

Conclusions:

DFT is a powerful tool for characterizing complex, disordered nanostructure systems.
Entrapped cations play a critical role in the stability and properties of uranyl-peroxide nanocapsules.
The combined experimental and theoretical approach provides a comprehensive understanding of these unique materials.