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Updated: May 22, 2026

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients
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Robot training of upper limb in multiple sclerosis: comparing protocols with or without manipulative task components.

Ilaria Carpinella1, Davide Cattaneo, Rita Bertoni

  • 1Biomedical Technology Department, Don Carlo Gnocchi Foundation Onlus IRCCS, 20148 Milan, Italy. icarpinella@dongnocchi.it

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
|May 25, 2012
PubMed
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Robot-assisted therapy for multiple sclerosis (MS) improves arm function. The reaching and manipulation (RMT) protocol showed greater gains in grasp ability compared to reaching tasks (RT) alone.

Area of Science:

  • Neurorehabilitation
  • Robotics in Medicine
  • Motor Control

Background:

  • Multiple sclerosis (MS) significantly impacts upper limb motor function.
  • Robot-based therapy offers a promising avenue for MS rehabilitation.
  • Standardized protocols are needed to optimize robotic interventions for MS.

Purpose of the Study:

  • To compare the efficacy of two robot-based upper limb rehabilitation protocols in individuals with MS.
  • To evaluate a protocol focused on reaching tasks (RT) versus one involving reaching and manipulation (RMT).

Main Methods:

  • A pilot study involving 22 MS subjects randomized into RT or RMT groups.
  • Both protocols comprised eight robot-assisted therapy sessions with resistive and perturbing forces.
  • Clinical and instrumental assessments were used to evaluate motor performance.

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Last Updated: May 22, 2026

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Published on: October 11, 2024

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07:52

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Main Results:

  • MS patients demonstrated adaptation to robotic forces and increased motor learning rates.
  • Robot-therapy significantly reduced arm tremor and improved arm kinematics and functional ability.
  • The RMT protocol yielded significantly greater improvements in grasp function (77.4% vs. 29.5%) compared to the RT protocol.

Conclusions:

  • Robot-based rehabilitation is effective in improving upper limb function in MS patients.
  • The RMT protocol, incorporating object manipulation, shows superior benefits for grasp-related movements.
  • Further research should explore longer training durations and advanced robotic tools for fine motor skill enhancement.