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Diffuse idiopathic skeletal hyperostosis prevalence in subjects with severe atherosclerotic cardiovascular diseases

Carmela Zincarelli1, Salvatore Iervolino, Matteo Nicola Dario Di Minno

  • 1"Salvatore Maugeri" Foundation, IRCCS Scientific Institute, Telese Terme, Benevento, Italy.

Arthritis Care & Research
|May 25, 2012
PubMed

Insights

Diffuse idiopathic skeletal hyperostosis (DISH) affects 30.3% of cardiovascular patients. Older age and obesity are significant risk factors for developing DISH.

Area of Science:

  • Rheumatology
  • Cardiology
  • Epidemiology

Background:

  • Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by ossification at various entheseal sites.
  • Metabolic factors are implicated in DISH development.
  • Understanding DISH prevalence in cardiovascular disease (CVD) patients is crucial.

Purpose of the Study:

  • To determine the prevalence of DISH in patients with cardiovascular diseases.
  • To investigate the association between DISH and traditional vascular risk factors in this cohort.

Main Methods:

  • A cohort of 436 patients undergoing cardiac rehabilitation (post-CABG, HVR, or with CHF) was studied.
  • Patients underwent rheumatologic examination, blood tests, and chest radiography.
  • Data on age, BMI, blood pressure, and vascular risk factors were collected; DISH was diagnosed using Resnick and Niwayama criteria.

Main Results:

  • The overall prevalence of DISH was 30.3% in the study population (77.1% male, mean age 65.44 years).
  • Age (OR 1.076) and obesity (OR 2.28) were significant predictors of DISH.
  • Higher age and BMI correlated with increased DISH risk and C-reactive protein levels; other vascular risk factors showed no significant association.

Conclusions:

  • DISH prevalence is substantial (30.3%) in patients with cardiovascular diseases.
  • Advanced age and obesity are identified as key risk factors for DISH in this population.
  • Further research may explore the link between metabolic factors and DISH in cardiac patients.
Abstract

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