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Related Concept Videos

Raman Spectroscopy: Overview01:20

Raman Spectroscopy: Overview

The underlying principle of Raman spectroscopy is based on the interaction between light and matter, specifically molecules' inelastic scattering of photons. When a monochromatic beam of light, typically from a laser source, interacts with a sample, most scattered light has the same frequency as the incident light. This is known as Rayleigh scattering.
However, a small fraction of the scattered light exhibits a frequency shift due to the exchange of energy between the incident photons and the...
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...

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Related Experiment Video

Updated: May 22, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

Surface enhanced Raman spectroscopy on a flat graphene surface.

Weigao Xu1, Xi Ling, Jiaqi Xiao

  • 1Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

Proceedings of the National Academy of Sciences of the United States of America
|May 25, 2012
PubMed
Summary

Researchers developed a novel graphene-mediated Surface-Enhanced Raman Spectroscopy (G-SERS) substrate. This G-SERS tape offers cleaner, more stable signals for sensitive, real-time detection of trace analytes.

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A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
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A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants

Published on: February 19, 2016

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Last Updated: May 22, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
11:44

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

Published on: March 20, 2015

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants
08:13

A Filter-based Surface Enhanced Raman Spectroscopic Assay for Rapid Detection of Chemical Contaminants

Published on: February 19, 2016

Area of Science:

  • Nanotechnology
  • Spectroscopy
  • Materials Science

Background:

  • Surface-Enhanced Raman Spectroscopy (SERS) is a powerful analytical technique for sensitive detection.
  • Developing uniform and reproducible SERS substrates remains a key research challenge.
  • Recent advancements include using inert shells on nanoparticles to improve signal clarity.

Purpose of the Study:

  • To design and characterize a new graphene-mediated SERS (G-SERS) substrate.
  • To investigate the advantages of G-SERS over conventional SERS methods.
  • To demonstrate the application of G-SERS in real-time analyte detection.

Main Methods:

  • Fabrication of G-SERS substrates by depositing SERS-active metal nanoislands on atomically flat graphene.
  • Utilizing localized surface plasmon resonance to create electromagnetic "hot" spots.
  • Development of a freestanding, flexible G-SERS tape for practical applications.

Main Results:

  • G-SERS substrates provide an atomically flat hot surface for enhanced Raman signals.
  • G-SERS signals exhibit cleaner vibrational information, free from metal-molecule interactions.
  • The G-SERS substrate demonstrates enhanced stability against photo-induced damage.
  • Comparable enhancement factors to conventional SERS were achieved.

Conclusions:

  • G-SERS substrates offer significant advantages in signal quality and stability.
  • The developed G-SERS tape enables efficient and universal real-time detection of trace analytes.
  • This technology holds promise for various analytical applications requiring high sensitivity and reliability.