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Related Experiment Videos

Intracranial ependymomas in children.

J W Goldwein1, J M Leahy, R J Packer

  • 1Radiation Oncology Center, Hospital of the University of Pennsylvania, Philadelphia 19104.

International Journal of Radiation Oncology, Biology, Physics
|December 1, 1990
PubMed
Summary

Local control of intracranial ependymal tumors is crucial for treatment success. Higher radiation doses and Caucasian race are favorable prognostic factors for survival in pediatric patients.

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Medical and pediatric oncology·2001

Area of Science:

  • Pediatric Oncology
  • Neurosurgery
  • Radiation Oncology

Background:

  • Intracranial ependymal tumors are a significant challenge in pediatric neuro-oncology.
  • Treatment strategies have evolved, but local control remains a critical issue.

Purpose of the Study:

  • To evaluate treatment outcomes and identify prognostic factors for children with intracranial ependymal tumors.
  • To analyze the impact of various therapeutic modalities on survival and progression-free survival.

Main Methods:

  • Retrospective analysis of 51 children treated between 1970 and 1988.
  • Evaluation of factors including tumor resection extent, radiation dose, patient age, race, and chemotherapy use.
  • Calculation of 5-year actuarial survival and progression-free survival (PFS) rates.

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Main Results:

  • 5-year survival and PFS rates were 46% and 30%, respectively.
  • Local disease control was significantly better with tumor doses exceeding 4500 cGy and in Caucasian patients.
  • Survival was improved for patients over 4 years old, receiving local radiation doses above 4500 cGy, and for Caucasian patients.

Conclusions:

  • Inability to achieve local disease control is the primary cause of treatment failure.
  • Older age at diagnosis, higher local radiation dose, and Caucasian race are favorable prognostic indicators.
  • Extent of resection and chemotherapy did not significantly impact survival in this cohort.