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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

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Published on: June 2, 2014

Concurrent functional and structural cortical alterations in migraine.

Nasim Maleki¹, Lino Becerra, Jennifer Brawn

¹Department of Radiology, Children's Hospital Boston, Harvard Medical School, USA.

Cephalalgia : an International Journal of Headache

|May 25, 2012

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High frequency episodic migraine is linked to adaptive brain changes in sensory processing areas and maladaptive changes in emotional processing regions. These cortical alterations may reflect the brain

Area of Science:

Neuroscience
Neuroimaging
Migraine research

Background:

Migraine is associated with cortical structural and functional changes.
Understanding these alterations is key to identifying adaptive or maladaptive brain responses in migraineurs.

Purpose of the Study:

To investigate concurrent structural and functional cortical alterations in episodic migraine.
To compare brain changes in high-frequency (HF) and low-frequency (LF) migraineurs versus healthy controls (HC).

Main Methods:

High-resolution magnetic resonance imaging (MRI) was used.
Structural and functional cortical measures were compared between HF migraineurs (n=10), LF migraineurs (n=10), and HC (n=20).

Main Results:

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HF migraineurs showed increased post-central gyrus thickness (sensory face area) correlated with higher functional activation, suggesting adaptation.

Reduced cingulate cortex volume correlated with lower activation in HF patients, indicating potential maladaptive changes.

Insula showed significant structural and functional differences in HF vs. LF groups, possibly related to affective processing alterations.

Conclusions:

Migraineurs exhibit distinct adaptive and maladaptive responses in sensory and affective brain regions.
These differential patterns may represent the brain's response to the repeated challenges of migraine attacks.