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Related Experiment Video

Updated: May 22, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Concurrent macular corneal dystrophy and keratoconus.

Hossein Mohammad-Rabei¹, Ahmad Shojaei, Mehdi Aslani

¹Imam Hussein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Middle East African Journal of Ophthalmology

|May 25, 2012

Summary

This summary is machine-generated.

This case report details a rare instance of concurrent macular corneal dystrophy and keratoconus in a young woman presenting with progressive vision loss. Surgical intervention and histopathology confirmed both conditions, highlighting a unique clinical presentation.

Keywords:

Case Report Cornea Corneal Dystrophy Keratoconus Macular Corneal Dystrophy

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Last Updated: May 22, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Area of Science:

Ophthalmology
Corneal Diseases
Genetics

Background:

Macular corneal dystrophy (MCD) and keratoconus are distinct corneal conditions.
MCD is characterized by stromal opacities, while keratoconus involves progressive corneal thinning and bulging.
Concurrent presentation of both conditions is exceptionally rare.

Observation:

A 21-year-old female experienced 8 years of progressive bilateral visual loss.
Ophthalmic examination revealed hazy corneas, superficial and deep stromal opacities, and corneal thinning with bulging.
Corneal topography indicated a pattern consistent with keratoconus.

Findings:

Penetrating keratoplasty (PKP) was performed.
Histopathologic examination post-PKP confirmed the simultaneous presence of macular corneal dystrophy and keratoconus.
This confirmed a rare concurrent diagnosis in the affected eyes.

Implications:

This case underscores the importance of comprehensive ophthalmic evaluation, even in the presence of seemingly typical findings.
Recognizing rare concurrent corneal pathologies is crucial for appropriate management and surgical planning.
Further research may elucidate potential shared genetic or pathomechanistic links between these conditions.