Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Acute Coronary Syndrome IV: Interprofessional Care

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...

Pulmonary Embolism III: Nursing Management

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...

Clot Retraction and Fibrinolysis

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

High Modified 5 Factor Frailty Index is Associated With Worse PROMs and Decreased Return to Activities After 1 or 2 Level MI-TLIF.

Global spine journal·2025

Same author

Impact of pedicle screw accuracy on clinical outcomes after 1- or 2-level minimally invasive transforaminal lumbar interbody fusion.

Journal of neurosurgery. Spine·2025

Same author

The Impact of Preoperative Sagittal Imbalance on Long-term Postoperative Outcomes Following Minimally Invasive Laminectomy.

HSS journal : the musculoskeletal journal of Hospital for Special Surgery·2024

Same author

Morbidly Obese Patients Have Similar Clinical Outcomes and Recovery Kinetics After Minimally Invasive Decompression.

Spine·2024

Same author

Temporal Trends of Improvement After Minimally Invasive Transforaminal Lumbar Interbody Fusion.

Spine·2024

Same author

Practical Answers to Frequently Asked Questions in Anterior Cervical Spine Surgery for Degenerative Conditions.

The Journal of the American Academy of Orthopaedic Surgeons·2024

Search research articles

Related Experiment Video

Updated: May 22, 2026

Prehospital Thrombolysis: A Manual from Berlin

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Pre-hospital thrombolysis.

Aditi Vaishnav¹, Avani Vaishnav, Santosh Khandekar

¹Asian Heart Institute, G/N Block, Bandra Kurla Complex, Bandra (E), Mumbai 400 051.

The Journal of the Association of Physicians of India

|May 26, 2012

Summary

Pre-hospital thrombolysis (PHT) significantly reduces mortality for ST-elevation myocardial infarction (STEMI) patients in India compared to in-hospital treatments. Addressing delays and improving access to PHT can save heart muscle and lives, especially where percutaneous coronary intervention is unavailable.

More Related Videos

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Related Experiment Videos

Last Updated: May 22, 2026

Prehospital Thrombolysis: A Manual from Berlin

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Area of Science:

Cardiology
Emergency Medicine
Public Health

Background:

Coronary heart disease (CHD) and ST-elevation myocardial infarction (STEMI) are leading causes of mortality in India.
STEMI patients in India face higher mortality rates due to delayed access to evidence-based treatments, often linked to poverty.
Timely reperfusion therapy is critical for minimizing myocardial damage and improving outcomes in acute myocardial infarction (AMI).

Purpose of the Study:

To evaluate the effectiveness of Pre-Hospital Thrombolysis (PHT) compared to In-Hospital Thrombolysis (IHT) and Percutaneous Coronary Intervention (PCI) in reducing mortality for STEMI patients.
To identify strategies for reducing pre-hospital and in-hospital delays in initiating reperfusion therapy for AMI.
To assess the impact of different reperfusion strategies on patient outcomes in the Indian healthcare context.

Main Methods:

Review of existing studies and clinical trial data (RIKS-HIA, NRMI, CAPTIM, GRACIA-1) comparing PHT, IHT, and PCI.
Analysis of treatment guidelines from major cardiology organizations (AHA, ACC, NICE).
Consideration of factors influencing the implementation of PHT, including organizational challenges and regional healthcare systems.

Main Results:

PHT demonstrates superior outcomes compared to IHT, particularly in regions lacking immediate access to PCI.
Primary Percutaneous Coronary Intervention (PPCI) shows lower mortality and re-infarction rates when available within recommended timeframes.
Guidelines favor PHT emphasizing time-to-treatment, with PPCI as a preferred alternative if available within 90 minutes.

Conclusions:

PHT is a vital strategy to shorten delays in reperfusion therapy for STEMI, significantly improving patient survival.
Implementation of PHT faces organizational barriers that require tailored solutions based on regional healthcare infrastructure.
Optimizing the pre-hospital phase and ensuring timely access to either PHT or timely PPCI are crucial for reducing STEMI mortality.