[Rates of aberrant lymphocytes elimination in various bio-objects]

Rate of damaged cells elimination in mammals after prolonged irradiation modifies frequency of chromosomal aberrations (CAF) significantly. Hence, CAF is unlikely to be identical in a bio-object exposed to equal doses with varying dose rate for the reason of different periods of ionizing irradiation. This should be taken into account by designers of bio-dosimeters. Main time characteristics of chromosomal aberrations in mammals can be calculated from the experimentally evidenced CAF growth in the course of irradiation and decline afterwards. This assumption was tested using the data about disaster fighters at the Chernobyl nuclear power station and of experiments with chronic and fractionated exposure of rhesus macaques to 2.5 Gy (Cs137). The experimental doses ranged from 25 cGy to 250 cGy; dose rate made up 1.4 and 20 cGy/hr. Therapeutic doses were within the interval of 1.2 to 9.8 Gy. Rate of aberrant cells elimination was determined for two objects, i.e. humans and rhesus macaques. The follow-up period was approx. 6 years (61 to 2174 days). Elimination rate in the experiment was estimated using a proposed mathematical description of CAF dynamics in peripheral blood lymphocytes of monkeys. Elimination rates of aberrant peripheral lymphocytes in two bio-species were compared. The parameter is equal to (2 +/- 0.5).10(-3) d(-1) and (16 +/- 3) x 10(-3) d(-1) for the human and rhesus macaque, respectively.