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Related Experiment Videos

Acetazolamide alters temperature regulation during submaximal exercise.

W F Brechue1, J M Stager

  • 1Human Performance Laboratory, Indiana University, Bloomington 47405.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|October 1, 1990
PubMed
Summary

Acetazolamide (ACZ) impairs exercise by causing hypohydration, which negatively affects cardiovascular and thermoregulatory systems. This leads to reduced exercise tolerance despite maintained oxygen and carbon dioxide exchange.

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Area of Science:

  • Exercise Physiology
  • Cardiovascular Physiology
  • Thermoregulation

Background:

  • Acetazolamide (ACZ), a carbonic anhydrase inhibitor, reduces submaximal exercise tolerance.
  • This performance decrease occurs despite stable oxygen consumption and carbon dioxide removal.
  • ACZ's diuretic effect induces hypohydration, potentially impairing cardiovascular and thermoregulatory functions during exercise.

Purpose of the Study:

  • To investigate the role of hypohydration induced by ACZ in impairing exercise performance.
  • To examine the effects of ACZ on cardiovascular and thermoregulatory responses during submaximal exercise.

Main Methods:

  • Seven healthy males (21-35 years) participated in a double-blind, placebo-controlled crossover study.
  • ACZ was administered orally before exercise at 70% peak oxygen uptake on a cycle ergometer.

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  • Measurements included ventilation, gas exchange, body temperatures, sweat loss, stroke volume, and heart rate.

    • Main Results:

    • ACZ increased exercise minute ventilation but did not alter oxygen uptake or carbon dioxide output.
    • ACZ resulted in lower mean skin temperature, higher rectal and mean body temperatures, and reduced sweat loss.
    • Stroke volume decreased significantly, while arteriovenous oxygen difference increased, with an inverse relationship between heart rate and stroke volume.

    Conclusions:

    • Hypohydration induced by acetazolamide impairs cardiovascular function, evidenced by decreased stroke volume.
    • ACZ negatively impacts thermoregulation, leading to increased body temperature during exercise.
    • These cardiovascular and thermoregulatory impairments likely contribute to the reduced submaximal exercise tolerance observed with ACZ use.