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[Comparative analysis of mice models for preeclampsia]
L Doridot1, C Méhats, D Vaiman
1Inserm U1016, institut Cochin, 24, rue du Faubourg-Saint-Jacques, 75014 Paris, France.
Preeclampsia is a multifactorial disease of pregnancy. It is a major cause of maternal and perinatal mortality and morbidity and is defined by the de novo onset of hypertension and proteinuria after the 20th week of pregnancy. This pathology manifests during the early stages of pregnancy, making it hard to predict and very difficult to study in humans (presymptomatic phase and lack of tissues access). Animal models are therefore necessary to study the physiopathology of preeclampsia, however, since this pathology is specifically human, there are no spontaneous models. Animal models have thus been engineered. In this review, the models obtained in mice are described and compared. These models are essential for the development of new therapeutic strategies.
Preeclampsia is a multifactorial disease of pregnancy. It is a major cause of maternal and perinatal mortality and morbidity and is defined by the de novo onset of hypertension and proteinuria after the 20th week of pregnancy. This pathology manifests during the early stages of pregnancy, making it hard to predict and very difficult to study in humans (presymptomatic phase and lack of tissues access). Animal models are therefore necessary to study the physiopathology of preeclampsia, however, since this pathology is specifically human, there are no spontaneous models. Animal models have thus been engineered. In this review, the models obtained in mice are described and compared. These models are essential for the development of new therapeutic strategies.
