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Seroconversion of hepatitis B envelope antigen (HBeAg) by entecavir in a child with chronic hepatitis B

Mohammed Y Hasosah1, Heba S Ghandourah, Ashraf F Alsahafi

  • 1Department of Pediatric Gastroenterology, King Saud Bin Abdulaziz University for Health Sciences/National Guard Health Affairs, Jeddah, Saudi Arabia. hasosah2007@yahoo.com

Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
|May 26, 2012
PubMed

Insights

Hepatitis B virus (HBV) infection is a global health concern. This review examines entecavir treatment for chronic HBV in children, addressing the lack of established pediatric treatment guidelines.

Area of Science:

  • Hepatology
  • Virology
  • Pediatric Gastroenterology

Background:

  • Chronic Hepatitis B virus (HBV) infection poses a significant global health challenge.
  • Established treatment guidelines for adult HBV may not be suitable for pediatric populations.
  • Current FDA-approved antiviral therapies for children include interferon (IFN)-alpha and lamivudine.

Observation:

  • This review synthesizes literature on entecavir's efficacy in treating chronic HBV in pediatric patients.
  • It addresses the need for specific pediatric treatment guidelines.
  • The study highlights outcomes such as undetectable HBV DNA and Hepatitis B envelope antigen (HBeAg) loss/seroconversion.

Findings:

  • Entecavir treatment in children can lead to nondetectable serum HBV DNA.
  • Key treatment endpoints include Hepatitis B envelope antigen (HBeAg) loss and seroconversion.
  • A 1-year duration of entecavir therapy is evaluated for its effectiveness.

Implications:

  • Findings may inform the development of consensus guidelines for pediatric chronic HBV treatment.
  • Entecavir shows promise as a therapeutic option for children with chronic HBV infection.
  • Further research is warranted to establish optimal entecavir dosing and long-term safety in children.

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