Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone marrow cyto-morphological changes in multibacillary leprosy.

R Sen1, S D Chaudhary, V B Dixit

  • 1Department of Dermatology, Venerealogy and Leprosy, Medical College and Hospital, Rohtak.

Indian Journal of Leprosy
|July 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Outcomes Following Posterior Malleolus Fixation in Trimalleolar Ankle Fractures: A Prospective Study.

Malaysian orthopaedic journal·2026
Same author

Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments.

Aging cell·2025
Same author

OSAIRIS: Lessons Learned From the Hospital-Based Implementation and Evaluation of an Open-Source Deep-Learning Model for Radiotherapy Image Segmentation.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Vaccinating the vulnerable.

British dental journal·2021
Same author

Liming effects of poultry litter derived biochar on soil acidity amelioration and maize growth.

Ecotoxicology and environmental safety·2020
Same author

Darier's Disease (Clinical Study of 8 cases).

Indian journal of dermatology and venereology·2017
Same journal

Unilateral Cauliflower Ear due to Leprosy or Trauma - A Diagnostic Challenge.

Indian journal of leprosy·2018
Same journal

Pityriasis Rosea Localized to the Skin Patches of Leprosy. A Wolf's Isotopic Response?

Indian journal of leprosy·2018
Same journal

Cutaneous Sarcoidosis Misdiagnosed as Leprosy. Report of Two Cases and Review of Literature.

Indian journal of leprosy·2018
Same journal

Evaluation of New Antibacterial Drugs and their Combinations in a Murine Model to Identify Short Duration Alternative Chemotherapy for Leprosy.

Indian journal of leprosy·2018
Same journal

Evaluation of anti-bacterial activity of Rifapentine, Clarithromycin, Minocycline, Moxifloxacin, Ofloxacin and their combinations in Murine Model of Rifampicin Resistant Leprosy.

Indian journal of leprosy·2018
Same journal

Functioning and Disability in Leprosy.

Indian journal of leprosy·2018
See all related articles

Bone marrow examination of multibacillary leprosy patients revealed significant cytomorphological changes, including myeloid hyperplasia and megaloblastic changes. These findings highlight the systemic impact of leprosy and potential diagnostic challenges.

Area of Science:

  • Hematology
  • Infectious Diseases
  • Pathology

Background:

  • Leprosy, particularly the multibacillary form, can affect various organ systems.
  • Bone marrow involvement in leprosy is not fully understood.
  • Cytomorphological changes in bone marrow may offer insights into disease activity and host response.

Purpose of the Study:

  • To investigate cytomorphological alterations in the bone marrow of multibacillary leprosy patients.
  • To detect the presence of lepra bacilli in bone marrow.
  • To correlate bone marrow findings with clinical presentation and treatment status.

Main Methods:

  • Bone marrow aspiration and examination from 72 multibacillary leprosy patients.
  • Patients categorized into new cases (Group A) and treated cases (Group B).

Related Experiment Videos

  • Morphological analysis for cellularity, specific cell types, and presence of bacilli.

    • Main Results:

    • Myeloid hyperplasia observed, particularly in treated patients with erythema nodosum leprosum.
    • Megaloblastic changes in erythroblasts were frequent in both groups.
    • Elevated plasma cells and macrophages noted, with potential diagnostic confusion with multiple myeloma.
    • Bone marrow exhibited macrophage morphological changes, collections, and epithelioid cell granulomas.

    Conclusions:

    • Bone marrow examination reveals significant cytomorphological changes in multibacillary leprosy.
    • Findings suggest enhanced humoral response and potential for diagnostic dilemmas.
    • Further research is needed to elucidate the nature and significance of these bone marrow changes.