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Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine
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Coffee, colon function and colorectal cancer.

Paola Vitaglione1, Vincenzo Fogliano, Nicoletta Pellegrini

  • 1Department of Food Science, Federico II University of Naples, Parco Gussone, Portici (Napoli), Italy.

Food & Function
|May 26, 2012
PubMed
Summary

Coffee

Area of Science:

  • Gastroenterology and Oncology
  • Nutritional Science

Background:

  • Coffee's physiological effects are often attributed solely to caffeine.
  • Hundreds of bioactive compounds in coffee, including polyphenols and melanoidins, may offer protection against colorectal cancer (CRC).
  • Variability in coffee preparation (roasting, brewing) impacts compound concentration and potential health benefits.

Purpose of the Study:

  • To review mechanisms by which coffee consumption may influence colorectal cancer (CRC) risk.
  • To focus on components reaching the colon, such as polyphenols and dietary fiber (including melanoidins).
  • To examine coffee's effects on colon microbiota and the lumen environment in relation to cancer development.

Main Methods:

  • Literature review of studies investigating coffee's impact on CRC.

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  • Analysis of coffee components (polyphenols, melanoidins, dietary fiber) and their fate in the colon.
  • Consideration of espresso and filtered coffee preparations.

    • Main Results:

    • Coffee chlorogenic acids and dietary fiber, including melanoidins, show potential in reducing CRC risk.
    • These compounds may enhance colon motility and improve antioxidant status.
    • Coffee's influence on microbiota composition and the colon's reducing environment is a key factor.

    Conclusions:

    • Bioactive coffee components, particularly chlorogenic acids and fiber (melanoidins), may lower colorectal cancer risk.
    • Coffee consumption may positively influence colon health through increased motility and antioxidant effects.
    • Further research is needed to determine if coffee's colon benefits stem from a prebiotic effect.