Ventilatory control, exercise tolerance and respiratory dysfunction in Thai COPD patients

This study was designed to investigate a group of Thai COPD patients for their respiratory centre sensitivity while breathing room-air and during CO2 rebreathing, and tests to determine exercise tolerance and degrees of respiratory dysfunction. Results in 56 patients as compared with 45 age-matched healthy subjects disclosed comparable data between both subject groups, with the single exception that one-third (35.7%) of the patients experienced stronger ventilatory drive while breathing room-air and a lower musculo-ventilation transfer index during room-air breathing as well as CO2 rebreathing. According to the base-line dyspnoea index, the majority of Thai COPD patients in this study suffered from a very severe respiratory dysfunction, which correlated well with results of their basic physiologic tests.