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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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Cancer Stem Cells and Tumor Maintenance

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Related Experiment Video

Updated: May 22, 2026

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
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A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

Published on: February 28, 2020

Multifaceted tumor stromal fibroblasts.

Jie Li1, Lin Chen, Zhihai Qin

  • 1Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Beijing, China.

Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society
|May 26, 2012
PubMed
Summary

Tumor stromal fibroblasts have dual roles in cancer, acting as inflammation regulators and wound healers. Understanding these complex functions is crucial for developing targeted cancer therapies.

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Last Updated: May 22, 2026

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
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Published on: October 25, 2011

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08:39

Three-dimensional Co-culture Model for Tumor-stromal Interaction

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Area of Science:

  • Oncology
  • Cell Biology
  • Immunology

Background:

  • Tumors are complex tissues comprising neoplastic and stromal cells.
  • Tumor stromal fibroblasts significantly influence tumor development.
  • Fibroblast functions in tumors are multifaceted and context-dependent.

Purpose of the Study:

  • To review the dual characteristics of tumor stromal fibroblasts.
  • To discuss their roles in tumor immunity and wound healing.
  • To highlight the importance of considering these dual roles in cancer research.

Main Methods:

  • Literature review of current knowledge on tumor stromal fibroblasts.
  • Analysis of fibroblast functions as inflammation regulators.
  • Examination of fibroblast roles in extracellular matrix remodeling and wound healing.

Main Results:

  • Fibroblasts regulate tumor immunity through cytokine secretion.
  • Fibroblasts contribute to wound healing by remodeling the extracellular matrix.
  • Fibroblasts can participate in the foreign body reaction.

Conclusions:

  • Tumor stromal fibroblasts exhibit "two-faced" characteristics.
  • Both pro-tumor and anti-tumorigenic roles of fibroblasts exist.
  • Targeting cancer-associated fibroblasts requires careful consideration of their complex functions.