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Updated: May 22, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Antifungal activities of new coumarins
Ahmed A Al-Amiery1, Abdul Amir Hassan Kadhum, Abu Bakar Mohamad
1Chemical Engineering Faculty, University of Kabengassan Malaysia-UKM, Selangor 43000, Malaysia. dr.ahmed1975@gmail.com
Abstract:
Newly synthesized coumarins 4-((5-mercapto-4-phenyl-4H-1,2,4-triazol-3-yl)-methoxy)-2H-chromen-2-one and 4-((5-(phenylamino)-1,3,4-thiadiazol-2-yl)-methoxy)-2H-chromen-2-one were tested against selected types of fungi and showed significant activities. DFT calculations of the synthesized coumarins were performed using molecular structures with optimized geometries. Molecular orbital calculations provide a detailed description of the orbitals, including spatial characteristics, nodal patterns, and the contributions of individual atoms.
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