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Updated: May 22, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Enantioselective sensing of chiral amino alcohols with a stereodynamic arylacetylene-based probe
Daniel P Iwaniuk1, Keith W Bentley, Christian Wolf
1Department of Chemistry, Georgetown University, Washington, District of Columbia 20057, USA.
Abstract:
Enantioselective induced circular dichroism analysis of amino alcohols has been accomplished using a conformationally flexible arylacetylene-based probe exhibiting two terminal aldehyde groups. The chirality of the amino alcohol substrates is imprinted on the stereodynamic receptor upon [1 + 2] condensation, which ultimately generates a strong chiroptical response. The distinct induced circular dichroism effects of the diimines obtained can be used for enantioselective sensing and enantiomeric excess determination of a wide range of substrates.
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