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Draft genome sequence of an antibiotic-resistant Propionibacterium acnes strain, PRP-38, from the novel type IC

Andrew McDowell1, Judit Hunyadkürti, Balázs Horváth

  • 1Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, United Kingdom.

Journal of Bacteriology
|May 26, 2012
PubMed

Insights

We present the draft genome sequence of an antibiotic-resistant Propionibacterium acnes (P. acnes) strain, PRP-38. This bacterium is linked to acne vulgaris and belongs to a novel type IC cluster.

Area of Science:

  • Microbiology
  • Genomics
  • Dermatology

Background:

  • Propionibacterium acnes (P. acnes) is a Gram-positive bacterium commonly associated with acne vulgaris.
  • Antibiotic resistance in P. acnes is a growing concern for treating acne vulgaris.

Purpose of the Study:

  • To present the draft genome sequence of an antibiotic-resistant P. acnes strain.
  • To characterize the P. acnes strain PRP-38, isolated from an acne patient.

Main Methods:

  • Whole-genome sequencing was performed on the P. acnes strain PRP-38.
  • Bioinformatic analysis was used to assemble and annotate the draft genome.

Main Results:

  • The draft genome sequence of the antibiotic-resistant P. acnes strain PRP-38 was successfully generated.
  • The strain PRP-38 was identified as belonging to the novel type IC cluster.

Conclusions:

  • The genome sequence provides a valuable resource for understanding antibiotic resistance mechanisms in P. acnes.
  • Identification of the novel type IC cluster may offer insights into P. acnes pathogenesis and epidemiology.

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