Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Sex Linked Disorders

Sex Linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.

Sex-linked Disorders

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.

Personality Disorders: Schizotypal and Histrionic

Personality Disorders: Schizotypal and Histrionic

Schizotypal personality disorder and histrionic personality disorder are two distinct psychological conditions classified under personality disorders, each characterized by unique behavioral patterns and social difficulties. Both disorders significantly affect interpersonal relationships and emotional well-being, leading to social isolation and frustration.
Schizotypal Personality Disorder: Eccentric Behavior and Social Withdrawal
Schizotypal personality disorder is marked by odd or eccentric...

Bacterial Phylum Spirochaetes

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...

Barrett Esophagus-II: Clinical Manifestations and Management

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...

Cushing Syndrome II: Pathophysiology

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low-Density Lipoprotein Cholesterol Goal Attainment in Indian Patients With Coronary Artery Disease: A Nationwide Study.

JACC. Asia·2026

Same author

Different Methods of Low-density Lipoprotein Cholesterol Estimation and the Impact on Lipid-lowering Therapy in Patients with Coronary Artery Disease.

The Journal of the Association of Physicians of India·2026

Same author

Sarcopenia and sarcopenic obesity in type 2 diabetes mellitus and cardiovascular disease: current perspective and narrative review.

Endocrine regulations·2025

Same author

Optimizing Cardiovascular Outcomes With Bisoprolol: An Evidence-Based Perspective.

Cureus·2025

Same author

Insights into the molecular mechanism of pulmonary vein stenosis in pediatric patients with congenital heart disease.

JTCVS open·2025

Same author

Prevalence of stage B heart failure in patients undergoing echocardiography during regular clinical practice.

Indian heart journal·2025

Search research articles

Related Experiment Video

Updated: May 22, 2026

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Published on: July 15, 2016

Brooke-spiegler syndrome: a rare entity.

Kajal Manchanda¹, Manish Bansal, Aakash Amar Bhayana

¹Departments of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

International Journal of Trichology

|May 26, 2012

Summary

Brooke-Spiegler syndrome (BSS) is a rare genetic disorder causing multiple skin tumors. This case highlights familial adnexal tumors, confirming BSS diagnosis through clinical and histopathological findings.

Keywords:

Brooke-Spiegler cylindromas trichoepithelioma

More Related Videos

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Related Experiment Videos

Last Updated: May 22, 2026

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Observing Mitotic Division and Dynamics in a Live Zebrafish Embryo

Published on: July 15, 2016

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Primary Sjogren's Syndrome Associated with Lung Adenocarcinoma: Probing the Potential Common Pathogenic Mechanisms and Experimental Verification

Published on: September 20, 2024

Area of Science:

Dermatology
Genetics
Oncology

Background:

Brooke-Spiegler syndrome (BSS) is an autosomal dominant disorder.
It is characterized by the development of multiple adnexal tumors, including cylindromas, trichoepitheliomas, and spiradenomas.

Observation:

A 35-year-old female presented with a 30-year history of asymptomatic nodular lesions on her face and scalp.
A strong family history of similar lesions was noted across multiple generations.
Physical examination revealed characteristic facial and scalp nodules consistent with trichoepitheliomas and cylindromas.

Findings:

Histopathological examination confirmed the presence of trichoepitheliomas on the face and cylindromas on the scalp.
The clinical presentation and histopathological results were diagnostic of Brooke-Spiegler syndrome.

Implications:

This case underscores the importance of recognizing familial patterns in adnexal tumors.
Accurate diagnosis of BSS is crucial for genetic counseling and potential future management strategies.
Further research into the genetic underpinnings and therapeutic options for BSS is warranted.