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Updated: May 22, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

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Published on: February 8, 2019

Peripheral giant cell granuloma.

Padam Narayan Tandon1, S K Gupta, Durga Shanker Gupta

  • 1Department of Oral and Maxillofacial Surgery, Teerthanker Mahaveer Dental College and Research Centre, Delhi Road, Moradabad, India.

Contemporary Clinical Dentistry
|May 26, 2012
PubMed
Summary

Peripheral giant cell granuloma, a common oral lesion, is often reactive. A case report details complete excision of a maxillary lesion in a young female, with no recurrence after 6 months.

Keywords:
JawPeripheral giant cell granuloma/giant cell epulisreactive

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Area of Science:

  • Oral Pathology
  • Oral Surgery

Background:

  • Peripheral giant cell granuloma (PGCG) is the most common oral giant cell lesion.
  • It presents as a purplish-red nodule with multinucleated giant cells, mononuclear stromal cells, and extravasated red blood cells.
  • PGCG is considered reactive, possibly due to local irritation or trauma, rather than a true neoplasm.

Observation:

  • This article presents a case of PGCG in the maxillary anterior region of a 22-year-old female.
  • The lesion was characterized by its typical histological features.

Findings:

  • The PGCG was completely excised surgically, reaching the periosteum.
  • Post-operative follow-up for 6 months revealed no residual or recurrent swelling.
  • No bony defect was apparent in the biopsy area after 6 months.

Implications:

  • Surgical excision to the periosteum is an effective treatment for peripheral giant cell granuloma.
  • Complete removal ensures favorable outcomes with no recurrence.
  • This case highlights the importance of thorough surgical management for oral giant cell lesions.