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Updated: May 22, 2026
The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques
Published on: July 3, 2014
Histopathological analogies in chronic pulmonary lesions between cattle and humans: basis for an alternative animal
Rafael Ramírez-Romero1, Alicia M Nevárez-Garza, Luis E Rodríguez-Tovar
1Pathobiology Group, Faculty of Veterinary Medicine, Autonomous University of Nuevo León, Avenida Universidad S/N Ciudad Universitaria, 66451 San Nicolas de los Garza, NL, Mexico.
Abstract:
Most of the natural cases of pneumonia in feedlot cattle are characterized by a longer clinical course due to chronic lung lesions. Microscopically, these lesions include interstitial fibroplasia, bronchitis, bronchiectasis, bronchiolitis obliterans, and epithelial metaplasia of the airways. Herein, the aim was to review, under a medical perspective, the pathologic mechanisms operating in these chronic pneumonic lesions in calves. Based on the similarities of these changes to those reported in bronchiolitis obliterans/organising pneumonia (BO/OP) and chronic obstructive pulmonary disease (COPD) in human beings, calves are proposed as an alternative animal model.
