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Right dorsal colitis.

L F Karcher1, S G Dill, W I Anderson

  • 1Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca.

Journal of Veterinary Internal Medicine
|September 1, 1990
PubMed
Summary
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Nonsteroidal anti-inflammatory drugs (NSAID) can cause ulcerative colitis in horses, specifically affecting the right dorsal colon. This condition may manifest as colic, diarrhea, or weight loss, and can be fatal.

Area of Science:

  • Veterinary Medicine
  • Equine Gastroenterology
  • Toxicology

Background:

  • Ulcerative colitis in horses can present with varied clinical signs, including colic, diarrhea, and weight loss.
  • A significant number of affected horses had a history of hypovolemia and NSAID administration prior to illness.

Purpose of the Study:

  • To investigate the potential link between NSAID administration and ulcerative colitis in the right dorsal colon of horses.
  • To identify a previously unreported manifestation of NSAID toxicity in equine medicine.

Main Methods:

  • Diagnosis of ulcerative colitis was performed via necropsy or exploratory celiotomy and biopsy in 13 horses.
  • Experimental induction of the condition in two horses using high-dose phenylbutazone and restricted water intake.

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Main Results:

  • Ulcerative colitis localized to the right dorsal colon was diagnosed in 13 horses presenting with colic, diarrhea, or weight loss.
  • Experimental administration of high-dose phenylbutazone and water restriction successfully reproduced ulcerative colitis in the right dorsal colon of two horses.
  • Lesions were evident at necropsy 11 and 15 days post-treatment initiation.

Conclusions:

  • Localized ulcerative lesions in the right dorsal colon represent a potential manifestation of NSAID toxicity in horses.
  • This finding suggests a need for careful monitoring of horses receiving NSAIDs, particularly at high doses or in conjunction with dehydration.