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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: May 22, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
09:43

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics

Published on: March 1, 2022

Osteoanabolics.

Vishal Gupta1, Mitul Abhaykumar Shah, Sagar Kirtibhai Shah

  • 1Department of Endocrinology and Medicine, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India.

Indian Journal of Endocrinology and Metabolism
|May 26, 2012
PubMed
Summary
This summary is machine-generated.

Osteoporosis treatments aim to increase bone mass, a key factor in bone strength and fracture risk. This review covers current and future therapies for boosting bone mass, addressing organic and inorganic approaches.

Keywords:
Bone remodelingosteo-anabolicsosteoporosisteriparatide

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Last Updated: May 22, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
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Area of Science:

  • Bone biology and osteoporosis research.

Background:

  • Osteoporosis is defined by low bone mass and impaired bone quality, leading to increased fracture risk.
  • Bone mass is a primary determinant of bone mechanical strength, with low levels strongly correlating with future fractures.

Purpose of the Study:

  • To review existing and emerging therapies that increase bone mass.
  • To discuss both organic and inorganic approaches for enhancing bone mineral density.

Main Methods:

  • Literature review of scientific publications on osteoporosis therapies.
  • Analysis of current and prospective treatments targeting bone mass augmentation.

Main Results:

  • Osteoanabolic therapies are defined as treatments that increase bone mass.
  • Bone mass is a critical component of skeletal integrity and fracture prevention.

Conclusions:

  • Increasing bone mass is the central goal of osteoanabolic therapies.
  • A comprehensive understanding of available and future therapies is crucial for managing osteoporosis effectively.