Related Experiment Video
Updated: May 22, 2026

Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
Published on: December 27, 2024
Incidence of gall stone formation in acromegalic patients on octreotide therapy
Aditi A Chakravarty1, Ajay Ajmani, Smita Manchanda
1Department of Endocrinology, Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Objective:
Octreotide, a long-acting synthetic somatostatin analog, has been widely used for ac-romegalic patients. Gastrointestinal (GI) side effects and gall stones are predominant side effects. We report incidence of gall stones in our cohort of acromegalic patients treated with octreotide therapy.
Design:
Retrospective case observational study.
Setting:
Endocrinology Unit, Dr. Ram Manohar Lohia, Hospital, New Delhi.
Materials And Methods:
Patients of acromegaly on primary or secondary octreotide therapy.
Intervention:
Patients were enquired regarding complaints related to the GI system and their medical records were reviewed. Ultrasound films at various intervals while on octerotide therapy were evaluated by the radiologist for presence of sludge and development of gall stones.
Results:
Of seven patients, five developed gallstones and sludge was seen in three patients at intervals ranging from 11 to 36 months postoctreotide initiation.
Conclusion:
A high incidence of gall stone formation in the present study as compared to the West was noted, the reasons for which are not clear.
Related Concept Videos
Cholecystitis
Acute Pancreatitis II: Clinical Manifestations and Management
Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids
However, this neutralization reaction between...
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
Gallbladder
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...