Related Experiment Video
Updated: May 22, 2026

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
[Endotoxin (LPS) in the pathogenesis of atherosclerosis]
Abstract:
Recent data on the processes underlying atherogenesis indicate the significant role of endotoxin (lipopolysaccharide - LPS) of the intestinal microflora in the development of vascular lesions. This paper summarizes the literature and material results of their research on the participation of LPS gramnegativnyh bacteria in the initiation and progression of atherosclerosis. We prove that the LPS of gram-negative bacteria interact with TLR4, triggers cytokine cascade with the subsequent formation of atheroma.
Related Concept Videos
Formation of Lipopolysaccharides
Atherosclerosis I: Introduction
Bacterial Toxins
Coronary Artery Disease II: Pathophysiology
Inflammation
Myasthenia Gravis ll: Pathophysiology

