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Updated: May 22, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
Published on: December 27, 2016
[Apoptosis modulation by PMA occurs independently of TsPO expression in squamous cell carcinoma cells]
Abstract:
Phorbol esters are known to modulate protein kinase C activity - enzyme involved in cell proliferation, differentiation and apoptosis regulation in skin cells. Besides it phorbol-12-myristate 13-acetate was shown possible to modulate promoter activity of TsPO - protein that is involved in steroidogenesis and cell proliferation regulation. Caspase-3 and TsPO expression was measured in squamous cell carcinoma cells after incubation with phorbol-12-myristate 13-acetate and ultraviolet radiation. Following alterations of TsPO and caspase-3 levels are explained by different mechanisms of regulation.
Insights
Phorbol esters affect skin cell protein kinase C, influencing proliferation and apoptosis. Phorbol-12-myristate 13-acetate alters TsPO and caspase-3 expression in cancer cells via distinct regulatory pathways.
Area of Science:
- Biochemistry
- Molecular Biology
- Dermatology
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