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Change in high-sensitive cardiac troponin T on hypertensive treatment

Satoshi Hoshide1, Motoki Fukutomi, Kazuo Eguchi

  • 1Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan. hoshide@jichi.ac.jp

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|May 29, 2012
PubMed

Insights

Amlodipine significantly reduced highly sensitive cardiac troponin T (Hs-cTnT) levels in hypertensive patients, unlike Losartan/hydrochlorothiazide, particularly in those with elevated baseline Hs-cTnT. This suggests amlodipine offers a cardiovascular benefit.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hypertension Management

Background:

  • Elevated cardiac troponin levels are associated with increased cardiovascular risk.
  • Losartan/hydrochlorothiazide (LOS/HCTZ) and amlodipine are common antihypertensive treatments.
  • Comparing their effects on cardiac biomarkers like highly sensitive cardiac troponin T (Hs-cTnT) is clinically relevant.

Purpose of the Study:

  • To compare the impact of Losartan/hydrochlorothiazide (LOS/HCTZ) versus amlodipine on highly sensitive cardiac troponin T (Hs-cTnT) levels in hypertensive patients.
  • To assess if amlodipine offers a greater reduction in Hs-cTnT compared to LOS/HCTZ.
  • To investigate treatment effects stratified by baseline Hs-cTnT levels.

Main Methods:

  • Randomized controlled trial involving 78 hypertensive patients.
  • Treatment arms: Losartan/hydrochlorothiazide (LOS/HCTZ) and amlodipine.
  • Duration of treatment: 8 weeks.
  • Measurements included clinic and 24-hour blood pressure, and serum Hs-cTnT levels.

Main Results:

  • Both LOS/HCTZ and amlodipine effectively reduced blood pressure to a similar extent.
  • Amlodipine significantly decreased Hs-cTnT levels (P < .05).
  • No significant reduction in Hs-cTnT was observed with LOS/HCTZ, especially in patients with higher baseline Hs-cTnT levels.

Conclusions:

  • Amlodipine demonstrated a superior effect in reducing Hs-cTnT levels compared to LOS/HCTZ.
  • This beneficial effect of amlodipine was more pronounced in hypertensive patients with elevated baseline Hs-cTnT.
  • Amlodipine may offer additional cardiovascular protection beyond blood pressure control in specific patient subgroups.

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