Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 22, 2026

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

Published on: April 28, 2022

A new overtraining protocol for mice based on downhill running sessions.

Bruno C Pereira¹, Luís A L Filho, Guilherme F Alves

¹School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Clinical and Experimental Pharmacology & Physiology

|May 29, 2012

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fermented probiotic dairy products with buriti and orange byproducts enhance gut and bone health.

Food research international (Ottawa, Ont.)·2025

Same author

Effects of Ultra-Processed Diets on Adiposity, Gut Barrier Integrity, Inflammation, and Microbiota in Male and Female Mice.

Nutrients·2025

Same author

Interleukin-6 modulates endoplasmic reticulum stress signaling and mitochondrial protein complexes in the kidney following acute exhaustive exercise.

Cell stress & chaperones·2025

Same author

Vildagliptin modulates the microbiota and induces an immunometabolic profile compatible with neuroprotection in type 2 diabetes.

Scientific reports·2025

Same author

Consumption of yogurts containing buriti pulp and fermented milks containing orange bagasse increases the response of the endogenous antioxidant system and the expression of heat shock proteins in healthy rats.

Food research international (Ottawa, Ont.)·2025

Same author

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity.

The Journal of physiology·2025

A new downhill running protocol effectively induced non-functional overreaching in all mice studied. This overtraining method significantly impacted performance metrics, highlighting its efficacy in research settings.

Area of Science:

Exercise Physiology
Animal Models in Research

Background:

Non-functional overreaching is a state of fatigue that impairs performance.
Understanding overreaching mechanisms is crucial for optimizing training and preventing detraining.

Purpose of the Study:

To determine if a downhill running protocol could induce non-functional overreaching in mice.
To establish a reliable overtraining model for future research.

Main Methods:

Mice were divided into control, trained, and overtrained groups.
Bodyweight and food intake were monitored weekly.
Performance was assessed using incremental load tests and exhaustive tests before and after training/overtraining.

Main Results:

More Related Videos

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

Published on: February 2, 2019

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

Related Experiment Videos

Last Updated: May 22, 2026

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

A Simple and Inexpensive Running Wheel Model for Progressive Resistance Training in Mice

Published on: April 28, 2022

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice

Published on: February 2, 2019

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

The overtrained group showed decreased bodyweight and increased food intake compared to controls.

Performance parameters significantly increased in the trained group.

Performance parameters significantly decreased in the overtrained group.

Conclusions:

The downhill running protocol successfully induced non-functional overreaching in 100% of the mice.
This protocol provides a robust model for studying overtraining effects in animal research.