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Characterization of the novel HLA-DPB1*139:01 allele identified by sequence-based typing in a Chinese Han individual

D Wang1, Y Xu, L-M He

  • 1Immunogenetics Laboratory, Shenzhen Blood Center, Shenzhen, Guangdong, China.

Tissue Antigens
|May 29, 2012
PubMed

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Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...