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Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni
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Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni

Published on: January 14, 2018

Schistosomiasis.

Bruno Gryseels1

  • 1Institute of Tropical Medicine, Nationalestraat 155, B-2000 Antwerpen, Belgium. bgryseels@itg.be

Infectious Disease Clinics of North America
|May 29, 2012
PubMed
Summary
This summary is machine-generated.

Schistosomiasis is a tropical parasitic disease caused by Schistosoma worms, affecting millions globally. Diagnosis involves microscopy and serology, with praziquantel as the primary treatment.

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Area of Science:

  • Tropical medicine
  • Parasitology
  • Infectious diseases

Background:

  • Schistosomiasis is a debilitating tropical parasitic disease caused by blood flukes of the genus Schistosoma.
  • Affects millions worldwide, with major species including S. mansoni, S. japonicum, and S. haematobium, leading to intestinal, hepatosplenic, and urinary schistosomiasis.
  • While many infections are asymptomatic or mild, severe cases manifest with significant morbidity, and acute schistosomiasis presents as a flu-like illness.

Purpose of the Study:

  • To provide a comprehensive overview of schistosomiasis, covering its causative agents, clinical manifestations, diagnostic approaches, and current management and control strategies.

Main Methods:

  • Diagnosis relies on microscopic examination of stool or urine samples.
  • Serological tests and imaging techniques aid in diagnosis.
  • Information synthesized from existing literature on schistosomiasis epidemiology, clinical features, and treatment.

Main Results:

  • Key human schistosome species identified: S. mansoni, S. japonicum, and S. haematobium.
  • Clinical presentations range from asymptomatic infections to severe hepatosplenic and urinary schistosomiasis.
  • Praziquantel is the established drug of choice for treatment, effective against all species.

Conclusions:

  • Schistosomiasis remains a significant global health concern, particularly in tropical regions.
  • Effective diagnosis and treatment with praziquantel are crucial for disease management.
  • Preventive chemotherapy in at-risk populations is a cornerstone of current control efforts.