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Updated: May 22, 2026

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
Published on: March 17, 2023
Periodic sterility assessment of materials stored for up to 6 months at continuous microbial contamination risk:
Giovana Abrahão de Araújo Moriya1, Rafael Queiroz de Souza, Flávia Morais Gomes Pinto
1Department of Medical Surgical Nursing, School of Nursing, University of São Paulo, São Paulo, Brazil. gaamoriya@gmail.com
Abstract:
An investigation was conducted to test the hypothesis that the storage time of packaging sterility has no effect on contamination susceptibility even under deliberate bacterial exposure (Serratia marcescens). No growth of the test microorganisms was identified in the experimental group in any of the storage intervals (7, 14, 28, 90, and 180 days). Current recommendations/guidelines suggest that contamination of packaging occurs only because of events. This study, done in vitro, supports these recommendations.
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