Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An approach to the detection of pain from autonomic and cortical correlates.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2024
Same author

Modulation of the spinal N13 SEP component by high- and low-frequency electrical stimulation. Experimental pain models matter.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2023
Same author

Erratum to "How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex" [Clin. Neurophysiol. 132 (2021) 2989-2995].

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2022
Same author

How different experimental models of secondary hyperalgesia change the nociceptive flexion reflex.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021
Same author

Modulation of the N13 component of the somatosensory evoked potentials in an experimental model of central sensitization in humans.

Scientific reports·2021
Same author

Theta-burst versus 20 Hz repetitive transcranial magnetic stimulation in neuropathic pain: A head-to-head comparison.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2021
Same journal

Test-retest reliability of threshold-tracking TMS and peripheral nerve testing in healthy adults and individuals with chronic cervical spinal cord injury.

Neurophysiologie clinique = Clinical neurophysiology·2026
Same journal

Neurophysiological mechanisms of extracorporeal shock wave therapy in post-stroke spasticity.

Neurophysiologie clinique = Clinical neurophysiology·2026
Same journal

Reduced electroencephalogram power and no change in peak alpha frequency in individuals with chronic migraine: a cross-sectional investigation.

Neurophysiologie clinique = Clinical neurophysiology·2026
Same journal

Reading the palm with MScanFit MUNE in spinal muscular atrophy and Hirayama disease: a pilot study.

Neurophysiologie clinique = Clinical neurophysiology·2026
Same journal

Effects of non-invasive brain stimulation on gait and corticospinal plasticity in children and adolescents with cerebral palsy: A systematic review.

Neurophysiologie clinique = Clinical neurophysiology·2026
Same journal

Cortical connectivity abnormalities assessed by TMS-EEG in patients after a transient ischemic attack.

Neurophysiologie clinique = Clinical neurophysiology·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
06:04

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Published on: July 4, 2018

Objective pain diagnostics: clinical neurophysiology.

L Garcia-Larrea1

  • 1Inserm U1028, Central Integration of Pain Unit, Centre for Neuroscience of Lyon, University Claude-Bernard Lyon, University Hospital Pain Center, Neurological Hospital, 69003 Lyon, France. luis.larrea@univ-lyon1.fr

Neurophysiologie Clinique = Clinical Neurophysiology
|May 29, 2012
PubMed
Summary
This summary is machine-generated.

Neurophysiological techniques, especially laser-evoked potentials (LEPs), are crucial for diagnosing neuropathic pain (NP). These methods objectively assess somatosensory system function, aiding in timely and effective treatment.

More Related Videos

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Related Experiment Videos

Last Updated: May 22, 2026

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex
06:04

Objective Nociceptive Assessment in Ventilated ICU Patients: A Feasibility Study Using Pupillometry and the Nociceptive Flexion Reflex

Published on: July 4, 2018

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
07:28

A Protocol of Manual Tests to Measure Sensation and Pain in Humans

Published on: December 19, 2016

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

Area of Science:

  • Neurology
  • Pain Medicine
  • Neurophysiology

Background:

  • Chronic pain, particularly neuropathic pain (NP), affects millions globally, often leading to delayed diagnosis and treatment.
  • Objective confirmation of somatosensory system lesions is required for diagnosing definite NP.
  • NP commonly involves damage to pain-temperature pathways (A-delta and C-fibers).

Purpose of the Study:

  • To highlight the role of neurophysiological techniques in diagnosing neuropathic pain.
  • To emphasize the importance of objectively assessing somatosensory function for pain management.
  • To discuss methods for evaluating nociceptive pathways and their diagnostic utility.

Main Methods:

  • Review of neurophysiological techniques for assessing pain-temperature pathways (A-delta and C-fibers, spinothalamic tracts).
  • Focus on laser-evoked potentials (LEPs) as a reliable method for evaluating nociception.
  • Integration of LEPs with autonomic responses (e.g., galvanic skin response) and quantitative sensory testing (QST).
  • Consideration of standard nerve conduction velocities (NCV) and somatosensory evoked potentials (SEPs) for a comprehensive assessment.

Main Results:

  • Laser-evoked potentials (LEPs) are presented as the most accessible and reliable neurophysiological tool for assessing nociceptive function.
  • Combining LEPs with QST and autonomic responses enhances diagnostic accuracy for neuropathic pain.
  • Neurophysiological testing provides objective data to confirm lesions, determine affected subsystems, and correlate with imaging findings.
  • These techniques offer a 'physiological photograph' of somatosensory function, crucial for guiding therapy.

Conclusions:

  • Neurophysiological testing is essential for the objective diagnosis and management of neuropathic pain.
  • LEPs, particularly when combined with other methods, offer significant diagnostic value for nociceptive pathways.
  • Timely and accurate diagnosis through neurophysiological approaches facilitates optimized and rapid therapeutic interventions for NP.