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Updated: May 22, 2026
08:46
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
[Cancer, fertility preservation and gonadotropins]
M Grynberg1, M Even, A-L Berwanger da Silva
1Université Paris-Sud, 92140 Clamart, France. michael.grynberg@abc.aphp.fr
Summary
Oncofertility involves ovarian stimulation for fertility preservation. This review examines the potential risks of gonadotrophins in cancer patients, evaluating their role in tumorogenesis.
Area of Science:
- Reproductive Endocrinology
- Oncology
- Oncofertility
Background:
- Oncofertility services offer fertility preservation options for cancer patients.
- Ovarian stimulation for oocyte/embryo cryopreservation is a key component of oncofertility.
- Concerns exist regarding the potential tumorigenic role of pituitary gonadotrophins (FSH and LH) in cancer patients.
Purpose of the Study:
- To address questions surrounding exogenous gonadotrophin administration in cancer patients undergoing fertility preservation.
- To evaluate existing experimental and clinical data on the relationship between gonadotrophins and tumorogenesis.
Main Methods:
- Literature review of experimental and clinical studies.
- Analysis of data on gonadotrophin administration and tumor development.
- Examination of the role of sex hormones regulated by gonadotrophins in tumor growth.
Main Results:
- While gonadal and extragonadal tumors are often stimulated by sex hormones regulated by gonadotrophins, conclusive data on FSH and LH acting as direct tumor promoters is limited.
- The potential risks and benefits of ovarian stimulation in cancer patients require careful consideration.
Conclusions:
- Further research is needed to fully elucidate the complex relationship between gonadotrophins and tumorogenesis in the context of oncofertility.
- Individualized risk-benefit assessments are crucial for cancer patients considering fertility preservation involving ovarian stimulation.
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