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Related Concept Videos

Sperm Structure and Semen Composition01:22

Sperm Structure and Semen Composition

During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...

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The Examination of Peroxidase-Positive Leukocytes in Semen
04:36

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Published on: January 19, 2024

Ten years' experience with an external quality control program for semen analysis.

Con Mallidis1, Trevor G Cooper, Barbara Hellenkemper

  • 1Center of Reproductive Medicine and Andrology, University of Münster, Münster, Germany. con.mallidis@ukmuenster.de

Fertility and Sterility
|May 29, 2012
PubMed
Summary
This summary is machine-generated.

The German external quality control program for semen analysis (QuaDeGA) improved laboratory performance over 10 years. However, adherence to World Health Organization (WHO) guidelines remains low, with most labs using non-recommended methods.

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Area of Science:

  • Reproductive Medicine
  • Clinical Laboratory Science
  • Quality Control in Healthcare

Background:

  • External quality control programs are crucial for standardizing laboratory performance.
  • The German external quality control program for semen analysis (QuaDeGA) was established to improve diagnostic accuracy.
  • Assessing laboratory performance and adherence to guidelines is essential for reliable semen analysis.

Purpose of the Study:

  • To evaluate the performance of laboratories participating in the QuaDeGA program over its initial decade.
  • To assess the impact of the QuaDeGA program on laboratory practices and adherence to World Health Organization (WHO) guidelines.
  • To analyze trends in semen analysis techniques and their alignment with international standards.

Main Methods:

  • Retrospective analysis of 19 QuaDeGA quality control distributions.
  • Inclusion of data from 280 participating laboratories, primarily private urologic practices.
  • Evaluation of laboratory responses against a defined
  • target window
  • and assessment of adherence to WHO guidelines for semen analysis.

Main Results:

  • Participant numbers increased steadily, with private urologic practices forming the largest group.
  • Adoption of WHO-recommended Neubauer chambers and diluents increased, while morphology staining protocols decreased.
  • Less than 8% of laboratories fully complied with WHO guidelines; median-based ranking reduced performance variance but questioned ranking significance.

Conclusions:

  • Laboratories demonstrate low adherence to WHO semen analysis guidelines, frequently employing non-recommended methods.
  • Participation in the QuaDeGA program demonstrably improved laboratory performance.
  • While median-based ranking reduces inter-laboratory variance, its impact on the meaningfulness of performance rankings requires further consideration.