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Updated: May 22, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Neonatal soft tissue sarcomas.

Andrea Ferrari1, Daniel Orbach2, Iyad Sultan3

  • 1Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via G. Venezian, 1 20133 Milano MI, Italy.

Seminars in Fetal & Neonatal Medicine
|May 29, 2012
PubMed
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Soft tissue tumors in neonates present unique challenges. While vascular tumors are common and usually benign, aggressive fibrosarcomas and rhabdomyosarcomas require careful management, with neonates facing poorer prognoses for rhabdomyosarcoma.

Area of Science:

  • Pediatric Oncology
  • Surgical Pathology

Background:

  • Soft tissue tumors in neonates present significant diagnostic and therapeutic challenges.
  • Vascular tumors are the most common neonatal soft tissue neoplasms, typically benign but occasionally aggressive.
  • Infantile fibrosarcoma and rhabdomyosarcoma are key concerns in this age group.

Purpose of the Study:

  • To review the diagnostic and therapeutic challenges of soft tissue tumors in very young children.
  • To highlight the characteristics and management of vascular, fibroblastic, and malignant soft tissue tumors in neonates.

Main Methods:

  • Review of existing literature on neonatal soft tissue tumors.
  • Analysis of tumor types, behavior, and treatment outcomes.
  • Comparison of prognosis between neonatal and older pediatric populations.

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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

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Last Updated: May 22, 2026

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
07:15

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies

Published on: July 28, 2020

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Main Results:

  • Vascular tumors are prevalent and generally benign but can be life-threatening.
  • Fibroblastic tumors, like infantile fibrosarcoma, are locally aggressive; complete surgical resection is often curative but challenging due to location.
  • Rhabdomyosarcoma is the most frequent malignant soft tissue tumor, responding to chemotherapy and radiotherapy, though neonates have a worse prognosis.

Conclusions:

  • Neonatal soft tissue tumors require specialized management strategies.
  • Aggressive local control and consideration of systemic therapy are crucial for malignant types.
  • The poorer prognosis for neonatal rhabdomyosarcoma may stem from treatment-related factors, necessitating optimized therapeutic approaches.