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Vitamin K status in patients with short bowel syndrome

Patrycja Krzyżanowska1, Janusz Książyk, Małgorzata Kocielińska-Kłos

  • 1Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.

Clinical Nutrition (Edinburgh, Scotland)
|May 29, 2012
PubMed

Insights

Short bowel syndrome (SBS) patients may face vitamin K deficiency, impacting their health. This study assessed vitamin K status in SBS patients, finding potential deficiencies in some.

Area of Science:

  • Pediatric Gastroenterology
  • Nutritional Science
  • Hepatology

Background:

  • Short bowel syndrome (SBS) is associated with malabsorption of fat-soluble vitamins.
  • While deficiencies in vitamins A, D, E, and B1 are recognized, vitamin K status in SBS patients remains under-investigated.

Purpose of the Study:

  • To evaluate the body's vitamin K reserves in a cohort of pediatric patients with short bowel syndrome.
  • To identify the prevalence of vitamin K deficiency in this vulnerable population.

Main Methods:

  • The study included 33 patients diagnosed with SBS, ranging in age from 1 month to 16 years.
  • Vitamin K status was assessed by measuring plasma concentrations of PIVKA-II (protein induced by vitamin K absence or antagonist-II).

Main Results:

  • All patients exhibited normal coagulation parameters.
  • PIVKA-II levels indicating vitamin K deficiency were detected in 9.1% of the SBS patients.
  • Patients with cirrhosis and cholestasis had low PIVKA-II levels, but received regular vitamin K supplementation.

Conclusions:

  • Vitamin K deficiency is a potential complication in patients with short bowel syndrome.
  • Regular monitoring of vitamin K status is recommended for SBS patients, particularly those with liver complications.
Abstract

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