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Impact of systolic time intervals on the relationship between arterial stiffness and left ventricular hypertrophy

Ho-Ming Su1, Tsung-Hsien Lin, Po-Chao Hsu

  • 1Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan.

Atherosclerosis
|May 29, 2012
PubMed

Insights

Left ventricular systolic function, measured by the brachial pre-ejection period (bPEP) to brachial ejection time (bET) ratio, significantly impacts the association between arterial stiffness (baPWV) and left ventricular hypertrophy (LVH). Considering bPEP/bET is crucial for interpreting baPWV and LVH relationships.

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Clinical Physiology

Background:

  • Arterial stiffness, indicated by brachial-ankle pulse wave velocity (baPWV), is linked to left ventricular hypertrophy (LVH).
  • The relationship between baPWV and LVH is controversial when left ventricular systolic function is not considered.
  • The ratio of brachial pre-ejection period to brachial ejection time (bPEP/bET) serves as a key indicator of left ventricular systolic function.

Purpose of the Study:

  • To investigate the influence of bPEP/bET on the association between baPWV and LVH.
  • To clarify the controversial relationship between arterial stiffness and LVH by incorporating systolic function metrics.

Main Methods:

  • 1146 patients were analyzed, with measurements of baPWV and bPEP/bET using an ABI-form device.
  • Patients were stratified into four groups based on median values of bPEP/bET and baPWV.
  • Statistical analysis, including multivariate models, was employed to assess associations.

Main Results:

  • High baPWV (groups 3 and 4) and high bPEP/bET with low baPWV (group 2) were significantly associated with increased left ventricular mass index (LVMI) and LVH (P < 0.001).
  • Initially, baPWV showed a significant association with LVMI and LVH (P = 0.007 and P = 0.025, respectively).
  • Upon further adjustment for bPEP/bET, the significant association between baPWV and LVMI (P = 0.150) and LVH (P = 0.173) disappeared.

Conclusions:

  • The bPEP/bET ratio significantly modulates the relationship between baPWV and LVH.
  • Interpreting the link between baPWV and LVH requires consideration of the simultaneously measured bPEP/bET values.
  • Systolic function assessment is vital for a comprehensive understanding of arterial stiffness and cardiac remodeling.
Abstract

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