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Updated: May 22, 2026

Colony Forming Cell (CFC) Assay for Human Hematopoietic Cells
Published on: December 18, 2010
Older age and capacity of colony forming unit in autologous peripheral derived hematopoietic cells
S Civriz Bozdag1, M Bay, E Ayyıldız
1Department of Hematology, Ankara University School of Medicine, Ankara, Turkey. scivriz@hotmail.com
Background:
Aging decreases bone marrow cellularity and alters the frequencies of stem cells. Aged hematopoietic stem cells can differ from their younger counterparts in functional capacity.
Study Design And Methods:
We aimed to evaluate the relation between the age and the ability of colony forming capacity of peripheral blood-derived hematopoietic cell products collected for autologous stem cell transplantation (AHSCT).
Results:
Elderly patients could be mobilized with lower total collected CD34+ cells. Colony forming capacity did not differ between young and old patients.
Conclusion:
This results can be translated into clinic as higher numbers of AHSCT candidates over age 60.
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